Question: Question 3 Dose-Response Curve Substance A Substance B Substance A 100 - Therapeutic Effect Toxic 75- Effect Response (%) 50 25 - 6 8 10

Question 3 Dose-Response Curve Substance A Substance B Substance A 100 - Therapeutic Effect Toxic 75- Effect Response (%) 50 25 - 6 8 10 12 14 16 18 20 22 Dose (mg/kg) Using the dose-response curve above answer the following questions: a. Which substance has the highest potency? Explain your answer. Answer- Substance A reaches the 50% response at a lower dose compared to Substance B. Therefore, Substance A is more potent because a smaller dose is required to achieve the same effect. Explanation- Potency is defined as the amount of a substance required to produce an effect of given intensity. The more potent a substance is, the lower the dose required to achieve a given effect. b. Define NOEL. What is the NOEL range of substance B? NOEL- C. What is the ED50 and TD50 of substance A? How did you determine these values? d. The therapeutic index of substance B is 9. Comparing substance A to substance B, which one would be considered safer? Explain your answer. e. At what dose is the maximum toxic effect of substance A observed? Explain your answer. F . At what dose is threshold reached for substance B? What is the threshold of a substance

Step by Step Solution

There are 3 Steps involved in it

1 Expert Approved Answer

Step: 1 Unlock blur-text-image

Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock

Step: 3 Unlock

Students Have Also Explored These Related Accounting Questions!

KEEPING IT REAL SUAREZ COMPUTER CENTER In preparing for next year, on December 1, Troy Falco hired two hourly employees to assist with some troubleshooting and repair work. More information: Dec. 7...

1 At the market price of $8, the quantity demanded is units, and quantity supplied is units. 12- 11 At this price, exists. 10 At a market price of $4, now exists. 9- The market equilibrium exists at...

Please quality check my solutions for this advanced heat transfer problem. Show all work. Thank you. All original documents are located at the bottom. 3.9 COMPACT HEAT EXCHANGERS 3.9.10-1 3.9.10...

Integrative Case 6 O'Grady Apparel Company O'Grady Apparel Company was founded nearly 160 years ago when an Irish merchant named Garrett O'Grady landed in Los Angeles with an inventory of heavy...

Infomercial Entertainment, Inc. In the good ol' daysbefore cable TV, fax machines, and multimedia personal computersthe phrase, "... and now a word from our sponsor ..." usually meant just that....

London School of Science & Technology Qualification Unit number and title BTEC Level 5 HND Diploma Business UNIT 6: Business Decision Making Student name and ID number Assessor name Al Hassan Barrie...

microeconomics 5. Complements and substitutes Sean enjoys eating jelly sandwiches and drinking soda. He is particular about proportions, though: For every jelly sandwich he eats, he must drink...

Provide the following information about Pepsico industry. You will need to choose one NAIS code to answer the following questions. 1. Industry NAIS code and industry description 2. Industry size &...

Remaining Time: 51 minutes, 30 seconds. Question Completion Status 106 16 126 136 141 151 165 7 185 191 205 21 221 236 241 25 261 271 28 290 305 314 321 8303 Moving to another question will save this...

Need help for this questions This Question: 1 pt Time Rem 11 of 30 (30 complete) The set of international standards governing rights to intellectual property is called O A. WTO O B. TRIPS O C. IMF O...

Keep the Highest 2.3 / 5 1. Income inequality and the poverty rate The following table summarizes the income distribution for the town of Perkopia, which has a population of 10,000 people. Every...

Blade bending moments are being measured on a research wind turbine on a day in which the wind speed at the hub height is 9.0 m/s. A wind shear results in a higher wind speed of 12.0 m/s at the top...

You are in the process of winding up the field work on Top Stove Corporation, a company that manufactures and sells kerosene space heating stoves. To date, there has been every indication that the...

This week's assignment presented some challenges initially. Thankfully, the attached PDFs provided clarity regarding the lesson. I began by calculating the new standard deviation (SD), which is...

Q What is the function of anti-pumping in the circuit breaker?