Shown below is a segment of replicating DNA. A small part of the DNA sequence is magnified.$$

a$)$ Label the $5\text{'}$ and $3\text{'}$ ends by filling in the shaded boxes and show the direction of movement of replication forks by an arrow.$$

b$)$ Which strand in Region $1$ is the template for the leading strand: Top$/$ Bottom

c$)$ Draw the primer for the leading strand in Region $1$ and label its $5\text{'}$ and $3\text{'}$ ends.$$

d$)$ You isolate cells from a normal healthy individual and grow them in the following plates:$$

$+$Plate $1$ has TAT$-2,$ a compound known to activate telomerase.$$

$+$ Plate $2$ has ciprofloxacin, a compound that inhibits topoisomerase.$$

In which plate would DNA replication be inhibited and why?$$

e$)$ You identify a mutant cell that shows an increased error rate during replication. Which enzyme REMOVES the incorrect nucleotide during replication and what activity of the enzyme allows it to do so$?$