Question: Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a prodrug for 3

Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a prodrug for 3 that will have enhanced water solubility, include a synthesis for your proposed prodrug and explain how the lead will be released in vivo. Include diagrams and structures.

Structure 3 was identified as the new lead from 3-D QSAR studies.

1 2 log1/C=0.398+1.089+4.541 3

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