Warfarin (or Coumadin) is used to prevent blood clots in humans, but is a poison used...

Transcribed Image Text:

Warfarin (or Coumadin) is used to prevent blood clots in humans, but is a poison used to kill rats at high does (results in internal bleeding). Warfarin (W) binds to human plasma albumin (A) with the reaction shown below. The apparent data at 25°C for this reaction are AG=-30.8 KJ/mol, AH=-13.1 kJ/mol and AC,-0, which can be used to determine the equilibrium constant. W+AWA (a) What is the entropy change for this reaction at 25°C? (b) What is the fraction of unbound albumin over a temperature range of 0 to 50°C, assuming that concentrations of warfarin and human albumin are 0.0001 M. Warfarin (or Coumadin) is used to prevent blood clots in humans, but is a poison used to kill rats at high does (results in internal bleeding). Warfarin (W) binds to human plasma albumin (A) with the reaction shown below. The apparent data at 25°C for this reaction are AG=-30.8 KJ/mol, AH=-13.1 kJ/mol and AC,-0, which can be used to determine the equilibrium constant. W+AWA (a) What is the entropy change for this reaction at 25°C? (b) What is the fraction of unbound albumin over a temperature range of 0 to 50°C, assuming that concentrations of warfarin and human albumin are 0.0001 M.

Answer rating: 100% (QA)

To determine the entropy change Delta S for the reaction at 25C you can use the Gibbs free energy ch... View the full answer