Question: What is the difference between a 1 s t messenger and a 2 n d messenger in cell signaling? 1 s t messengers bind to

What is the difference between a 1st messenger and a 2nd messenger in cell signaling?
1st messengers bind to receptors; 2nd messengers are generated by upstream signaling events.
1st messengers bind to receptors; 2nd messengers are generated by downstream signaling events.
1st messengers bind to membranes; 2nd messengers are generated by upstream signaling events.
1st messengers bind to G proteins; 2nd messengers bind to the regulatory domain of nuclear receptors.
1st messengers bind to upstream receptors; 2nd messengers bind to downstream receptors.
What is the difference between a 1 s t messenger

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