- Which amino acid side chain could be utilized in an enzyme reaction mechanism that involves acid/base catalysis? - Suppose and enzyme has a serine that is involved in binding the substrate to the enzyme. If this amino acid were replaced with a different amino acid as the result of a mutation, what amino acid would be most likely to allow the enzyme to still function correctly? - What is the molecule that is changed as a result of an enzymatic reaction? - Why would an enzyme function less effectively in the presence of a molecule that resembles the substrate? - Suppose an enzyme has a glutamine side chain on its surface that is hydrogen bonded to water molecules surrounding the protein. If this amino acid were replaced with a different amino acid as the result of a mutation, what amino acid would be most likely to cause the enzyme to not function correctly? - Rational drug design involves making what kind of molecules that render enzymes inactive by binding very tightly and specifically to the enzyme