Biochemistry Concepts And Connections 2nd Edition Dean Appling, Spencer Anthony-Cahill, Christopher Mathews - Solutions

When binding of sequence-specific regulatory proteins such as lac repressor or CRP to its respective DNA binding site was studied in vitro, the rates of association were much higher than predicted by collision theory. Propose an explanation for this observation and a simple experimental test of
Cancer is thought to result in part from an increase in the spontaneous mutation rate in precancerous cells. At the same time, the DNA methylation pattern changes during oncogenic transformation. Identify a process by which DNA methylation might lead to increased mutagenesis.

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