(a) Write a mechanism for the esterification of propanoic acid with 18 O-labeled ethanol. Show clearly the...
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(a) Write a mechanism for the esterification of propanoic acid with 18O-labeled ethanol. Show clearly the fate of the 18O label.
(b) Acid-catalyzed hydrolysis of an unlabeled ester with 18O-labeled water (H2 18O) leads to incorporation of some 18O into both oxygens of the carboxylic acid product. Explain by a mechanism.
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Organic Chemistry structure and function
ISBN: 978-1429204941
6th edition
Authors: K. Peter C. Vollhardt, Neil E. Schore
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