Which of the following mutations would be LEAST likely to have any discernible phenotype on the individual?

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Which of the following mutations would be LEAST likely to have any discernible phenotype on the individual?
(A) Translocation of the last 1,000 base pairs of chromosome 1 onto chromosome 2
(B) Nondisjunction of chromosome 7 to produce trisomy-7
(C) Nondisjunction of chromosome 8 to produce monosomy-8
(D) Deletion of 400 base pairs, resulting in the loss of an enhancer

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