Question: Te E. coli chromosome is 1.28 mm long. Under optimal conditions, the chromosome is replicated in 40 minutes. (a) What is the distance traversed by

Te E. coli chromosome is 1.28 mm long. Under optimal conditions, the chromosome is replicated in 40 minutes.
(a) What is the distance traversed by one replication fork in 1 minute?
(b) If replicating DNA is in the B form (10.4 base pairs per turn), how many nucleotides are incorporated in 1 minute in one replication fork?
(c) If cultured human cells (such as HeLa cells) replicate 1.2 m of DNA during a ﬁve hour S phase and at a rate of fork movement one-tenth of that seen in E. coli, how many origins of replication must the cells contain?
(d) What is the average distance, in kilobase pairs, between these origins?

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