The first step in the biological degradation of histidine is formation of a 4-methylidcneirnidazol-5-one (MIO) by Cyclization

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The first step in the biological degradation of histidine is formation of a 4-methylidcneirnidazol-5-one (MIO) by Cyclization of a segment of the pep- tide chain in the histidine ammonia lyase enzyme. Propose amechanism.

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Organic Chemistry

ISBN: 9780495112587

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Authors: John McMurry

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Question Posted: Mar 08, 2011 05:48 AM

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The first step in the biological degradation of histidine is formation of a 4-methylidcneirnidazol-5-one (MIO) by Cyclization

Question:

н сн-он CH2 for -CH3 NH -СНз NHEnz NHEnz Enz Enz 4-Methylidene-5-imidazolone (MIO)

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Enz B Enz H CHOH HO N H CH3 NHEnz HCHOH H CH3 n...View the full answer

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