The chloromethylated polystyrene resin used for Merrifield solid-phase pep- tide synthesis is prepared by treatment of polystyrene

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The chloromethylated polystyrene resin used for Merrifield solid-phase pep- tide synthesis is prepared by treatment of polystyrene with chloromethyl methyl ether and a Lewis acid catalyst. Propose a mechanism for thereaction.

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Organic Chemistry

ISBN: 9780495112587

7 Edition

Authors: John McMurry

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Question Posted: Mar 08, 2011 05:48 AM

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The chloromethylated polystyrene resin used for Merrifield solid-phase pep- tide synthesis is prepared by treatment of polystyrene

Question:

сHа-ҫн + сHа-сн Cн-оCH-CI SnCl4 Polystyrene CH2CI

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Formation of cation HCCHC SnCl4 HCOCH SnC15 Ele...View the full answer

Organic Chemistry

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