Whether the ortho-carboxyl substituent acts as an intramolecular general-base catalyst or as an intramolecular nucleophilic catalyst can

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Whether the ortho-carboxyl substituent acts as an intramolecular general-base catalyst or as an intramolecular nucleophilic catalyst can be determined by carrying out the hydrolysis of aspirin with 18O-labeled water and determining whether 18O is incorporated into ortho-carboxyl-substituted phenol. Explain the results that would be obtained with the two types of catalysis
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Organic Chemistry

ISBN: 978-0131407480

4th edition

Authors: Paula Yurkanis Bruice

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