(a) According to Equation 24-2, if all conditions are constant, but particle size is reduced from 3 μm to 0.7 μm, by what factor must pressure be increased to maintain constant linear velocity?
(b) If all conditions except pressure are constant, by what factor will linear velocity increase if column pressure is increased by a factor of 10?
(c) With 0.7-μm particles in a 50-μm-diameter × 9-cm-long column, increasing pressure from 70 MPa to 700 MPa decreased analysis time by approximately a factor of 10 while increasing plate count from 12 000 to 45 000.38 Explain why small particles permit 10-fold faster flow without losing efficiency or, in this case, with improved efficiency.