Question: Do you expect a Pro Gly mutation in a surface-loop region of a globular protein to be stabilizing or destabilizing? Assume the mutant folds

Do you expect a Pro → Gly mutation in a surface-loop region of a globular protein to be stabilizing or destabilizing? Assume the mutant folds to a native-like conformation. Explain your answer in terms of the predicted enthalpic and entropic effects of the mutation on the ΔG for protein folding compared to ΔG of folding for the wild-type protein.

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