Perform the test in Problem 9.63, and report a p-value (two-tailed)? Endocrinology A study to assess the
Question:
Endocrinology
A study to assess the effect of a low-fat diet on estrogen metabolism recruited 6 healthy women ages 21€“32 [5]. The women were within 5% of their ideal body weight, were not participating in athletics, and were eating a typical American diet. For the first 4 weeks the women were fed a high-fat diet (40% of total calories from fat). They were then switched to a low-fat diet (25% of calories from fat) for 2 months. During the follicular phase of their menstrual cycle (days 5€“7), each woman was given a sugar cube with [3H] E2 (estradiol). This was done once during the high-fat period and again after the woman had been eating the low-fat diet for 2 months. The percentage of orally administered [3H]E2 excreted in urine as 16α-hydroxylated glucoronides is given in Table 9.17.
Table 9.17 Percentage of orally administered [3H]E2 excreted in urine as glucoronides of 16α-OHE1
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We note that all 6 differences shown above are positive so the sum of the positive ranks is 123456 21 In Appendix Table 11 we find that for n6 the twotailed critical value for testing at the 005 level ...View the full answer
