Using the results from Problem 13.74, obtain a measurement-error-corrected OR and 95% CI for each of the

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Using the results from Problem 13.74, obtain a measurement-error-corrected OR and 95% CI for each of the hormones?


The hormones in Table 13.51 were also included in the reproducibility study mentioned in Example 13.75 [36]. The intraclass correlation coefficient and sample size used for

each hormone are given in Table 13.52.

Table 13.51: Relative-risk estimates and 95% CIs for breast-cancer incidence from 1989 to June 1, 1994, in a nested case€“control study among 11,169 postmenopausal women in the NHS not taking hormone-replacement therapy in 1989, comparing women at the median value of the fourth quartile vs. women at the median value of the first quartile of the hormone distributions

 Median value 1st quartile Median value 4th quartile Hormone 95% CI RR Free estradiol (%) Estrone (pg/mL) Testosterone (n


Table 13.52: Intraclass correlation coefficients (ICCs) for selected hormones from the NHS reproducibility study, 1989

Number of subjects with Hormone ICC 3 replicates 2 replicates Total number of measurements Free estradiol (%) Estrone (p

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