1) The antidepressant fluoxetine sold under the brand name Prozac, can be prepared by a substitution...
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1) The antidepressant fluoxetine sold under the brand name Prozac, can be prepared by a substitution reaction of an alkyl chloride with phenol using a weak base to generate the phenoxide ion. CF, CH₂ CF₂ OH A) Identify the nucleophile in this reaction. B) Identify the electrophile in this reaction. CH₂ CH₂ H Prozac (fluoxetine) C) If the rate of reaction depends on the concentration of both alkyl chloride and phenol, is this an SNI or SN2 reaction? D) Identify the chiral center in the alkyl chloride starting material. E) Given that amines such as Prozac from salt with carboxylic acids, draw a carboxylic acid that might allow you to resolve the racemate of Prozac. CF₁ CH₁ 1) The antidepressant fluoxetine sold under the brand name Prozac, can be prepared by a substitution reaction of an alkyl chloride with phenol using a weak base to generate the phenoxide ion. CF, CH₂ CF₂ OH A) Identify the nucleophile in this reaction. B) Identify the electrophile in this reaction. CH₂ CH₂ H Prozac (fluoxetine) C) If the rate of reaction depends on the concentration of both alkyl chloride and phenol, is this an SNI or SN2 reaction? D) Identify the chiral center in the alkyl chloride starting material. E) Given that amines such as Prozac from salt with carboxylic acids, draw a carboxylic acid that might allow you to resolve the racemate of Prozac. CF₁ CH₁
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A The nucleophile in this reaction is OH as O is the most electr... View the full answer
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