Question: 4 Maonude. The Marondei (MN) Assay procedure involves breaking the DNA oflymphocytebloosampath powerdobofradiat,itmemeasuring efficiemoditsabilityrepairselfVarde are fragments of DNA that have not healed back into either


4 Maonude. The Marondei (MN) Assay procedure involves breaking the DNA oflymphocytebloosampath powerdobofradiat,itmemeasuring efficiemoditsabilityrepairselfVarde are fragments of DNA that have not healed back into either of two daughter nude after imadation The MN. assay entails scoringe um bomicronutheighthmumbtheesefficienthsubjects DN Aepasystem Theosresponsthe umladmicron undoitokinloboskbdphoafter invitriradiatoowholodoowithraysthedosrange Gywastudied Thierens et al, 1901. The data provided in table are fromone patient (male 54 y.o.) and represent the frequency of maranda numbers for six levels of radiation, 0, 0.5, 1, 2, 3, and 4G. Number of maorude 0 3 4 5 6 0 976 21 COOON DO 0.5936 61 Dose 1 895 94 (inGy 760207 32 SOONOH 83302 48531914735 11 2 (a Fit a Poisson regression, in which the number of micronudei is the response () and dose is a covariate (2). Hot Pusson intensity ) asa functiondose (b) What is the average number d maranda for dose of 35 G? Hit: Touse MATLABsg1mf withpo issodistribuaiodo'g linkThiwill estimate the regression coefficients needed for (bc). For plot useg 1mv.al Theatneetobeappropriateodandonevatodosas y-[zer($76);1one(21,)1 2tones , 1; ... zero$361one61 1 2tones , 1; Zer (895:one9431 2one41,)] zer 760 )1one807)12one321 3one($, zeros83 1one(302)12one97,1 3one(42,] 4one(6, 1;... zer (485 1one(319);12one($47 );13one(35 ,)1 4one($ 1)1... 5tones , 1; 6 one( , 1; x =zer (8713,1; 0. 5k one(9365 13 , 1;... one(895941 1 1. .. 2one($ 6(207321 , 1; ... 3one(583029 71 26 , 1; 4one48319 4 391 12+1 , 1; Therens, H, Val, A, and de Rider, L (1991). Blogical bosinetry using the maroudeus assay for lymphocytesrindivdiffieterindosrespondleith Hus ,615, 62330
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