Question: a) Define the term antagonist, and use your definition to explain briefly the sort of medicinal effect that a histamine H2 receptor antagonist has. (2

a) Define the term antagonist, and use your definition to explain briefly the sort of medicinal effect that a ‘histamine H2 receptor antagonist’ has. (2 marks)

b) Apply Lipinski’s Rules to the structure of ranitidine. What does your analysis tell you about the suitability of ranitidine as a drug? (5 marks)

N. 4 -NH Molecular Weight: 314.14 LogP: 1.23 IZ

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