Insulin has a conserved set of 3 aromatic residues in the region that binds to the insulin receptor. Surprisingly, a mutation of a conserved tyr in this region to glu does not perturb binding nearly as much as expected. Why is this result surprising?Explain

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The surprising result you described where a mutation of a conserved tyrosine Tyr to glutamic acid Glu in the region that binds to the insulin receptor does not perturb binding as much as expected coul... View the full answer