The clearance

(Cl)

using the

K

and

V

values in

{

(

:m(L)/(m)in)

}\ The HEALTHE NL Ed...\ prescribing docume.\ Infort\ The volume of distribution using the AUC (trapezoidal) method (

V_(AUC)

in

(L)/(k)g

)\ The fraction of the dose remaining in the body at time

9.2hr

(Fraction)\ The plasma concentration of kinetolol at time in

{

(

:m(g)/(L))

}\ The time for the plasma concentration to reach

4.58m(g)/(L)(T_(1)inhr)

\ The time for the fraction of the dose in the body to reach

0.873(T_(2)inhr)

\ The elimination rate of the drug at time

3.4hr

when the plasma concentration is

12.5m(g)/(L)

(dAe/dt in

m(g)/(h)r

)\ A new dose if a

C_(0)

of

58m(g)/(L)

is desired (Dose in

_(1)mg

)\ A new dose if a duration of effect of

27hr

is desired, assuming a minimum effective concentration of

8.3m(g)/(L)

(Dose

2inmg

)\ In another patient,

13.2%

of an iv bolus dose remains in the body at

105hr

following the drug injection. What is the half life of the drug in this new patient\ II. Please use equations only (no graph or linear regression analysis) to estimate the following kinetic parameters assuming that only two plasma concentrat

hr(12.5m(g)/(L))

and at

27hr(5.71m(g)/(L))

. Also be prepared to discuss in class the differences between the kinetic parameters obtained for this patient in secti\ The plasma half life in

{

(

:hr)

}\ The plasma concentration immediately after the drug injection in

{

(

:m(g)/(L))

}\ The volume of distribution (

V

in

(L)/(k)g

)\ The clearance (

Cl

in

m(L)/(m)in

\ \\\\table[[,,,Answers:,],[I. 1.

C_(0)(m(g)/(L))

,2. V

V_(EXT )((L)/(k)g)

,3.

K(hr^(-1))

,4.

t_((1)/(2))(hr)

,5.

AUC_(TRAP )

(mg.hr/L),6.

AUC_(COMP )

12. The time for the plasma concentration to reach 4.58mg/L(T1 in hr) 13. The time for the fraction of the dose in the body to reach 0.873(T2 in hr) 14. The elimination rate of the drug at time 3.4hr when the plasma concentration is 12.5mg/L(dAe/dt in mg/hr ) 15. A new dose if a C0 of 58mg/L is desired (Dose (in 1mg ) 16. A new dose if a duration of effect of 27hr is desired, assuming a minimum effective concentration of 8.3mg/L (Dose 2 in mg ) 17. In another patient, 13.2% of an iv bolus dose remains in the body at 105 hr following the drug injection. What is the half life of the drug in this new patient II. Please use equations only (no graph or linear regression analysis) to estimate the following kinetic parameters assuming that only two plasma concentrat hr(12.5mg/L) and at 27hr(5.71mg/L). Also be prepared to discuss in class the differences between the kinetic parameters obtained for this patient in secti 18. The plasma half life (t1/2 in hr) 19. The plasma concentration immediately after the drug injection (C0 in mgL) 20. The volume of distribution (V in L/kg ) 21. The clearance ( Cl in mL/min)