Question: What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized? DNA polymerase can join new nucleotides

What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized?
DNA polymerase can join new nucleotides only to the 3' end of a pre-existing strand, and the strands are antiparallel.
Helicases and single-strand binding proteins work at the 5' end.
DNA ligase works only in the 3'5' direction.
The The origins of replication occur only at the 5' end.
What is the basis for the difference in how the

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