Question: You are a preparative chemist and have been tasked with developing a method to purify a basic compound (pKa 8.5) from a reaction mixture containing

You are a preparative chemist and have been tasked with developing a method to purify a basic compound (pKa 8.5) from a reaction mixture containing four other compounds. The overall goal is high purity with the fewest number of injections possible to save time and solvent. The current method uses a purely silica based column with water and methanol as a mobile phase; the peaks have a shark fin shape. You may need to use MS for detection. What would you do to improve the method to reduce the overall time required to purify the entire sample? Be specific and justify your choices. Are there any other factors to consider regarding success?

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