The addition of hydrogen cyanide to benzaldehyde forms a compound called mandelonitrile. (R)-Mandelonitrile is formed from the hydrolysis of amygdalin, a compound found in the pits of peaches and apricots. Amygdalin is the principal constituent of laetrile, a compound that was once highly touted as a treatment for cancer. The drug was subsequently found to be ineffective. Is (R)-mandelonitrile formed by attack of cyanide ion on the Re face or the Si face of benzaldehyde?

Transcribed Image Text:

OH HCI CH CHC N excess mandelonitrile