Would the following alterations to Src be oncogenic? Explain. (a) The mutation of Tyr 527 to Phe.

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Would the following alterations to Src be oncogenic? Explain.
(a) The mutation of Tyr 527 to Phe.
(b) The replacement of Src residues 249 to 253 with the sequence APTMP.

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Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

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Question Posted: Apr 30, 2016 02:39 PM

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Would the following alterations to Src be oncogenic? Explain. (a) The mutation of Tyr 527 to Phe.

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a Yes because the phosphorylation of Tyr 527 is required for the autoinhibition of S...View the full answer

Fundamentals of biochemistry Life at the Molecular Level

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