High concentrations of denaturing agents such as urea or formamide (HCONH2) tend to favor a rodlike conformation

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High concentrations of denaturing agents such as urea or formamide (HCONH2) tend to favor a rodlike conformation for single-stranded DNA, rather than a flexible coil. What molecular interactions promote this behavior?
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Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

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