The reaction sequence shown below illustrates the synthesis of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), a powerful herbicide. A 1

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The reaction sequence shown below illustrates the synthesis of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), a powerful herbicide. A 1 : 1 mixture of the butyl esters of 2,4,5-T and its dichlorinated analog 2,4-D was used between 1965 and 1970 as a defoliant during the Vietnam War under the code name Agent Orange. Propose mechanisms for the reactions in the synthesis of this substance, whose effects on the health of those exposed to it remain topics of considerable controversy. 

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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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